Vanderbilt used another monster first half to roll to its ninth straight win.
Tiffany Clarke scored 25 points and grabbed 13 rebounds to lead the Commodores to a 76-57 victory at Ole Miss on Sunday.
It was the fourth double-double for Clarke, who entered the game with a team-high 15.7 points and 7.9 rebounds a game. Guard Jasmine Lister added 13 points and 10 assists for her second straight double-double and third of the season.
Vanderbilt (12-3, 2-0 SEC) led 40-18 at halftime — just three days after it had a 53-18 intermission advantage against Mississippi State.
Diara Moore scored 15 points for Ole Miss (7-8).
The Commodores next play at No. 18 South Carolina on Thursday.